Depending on what field you are going in to, I would take classes that are targeted at what interests you the most. If you can specialize or get a minor in something or certificate, it will show that not only are you focused and driven, but can also handle multiple disciplines or areas at once. If you are planning on going into the medical field, make sure you are strong in one of the sciences (biology, chemistry, anatomy, physics, engineering). If you are planning on going in to business or being an entrepreneur, make sure you take classes in public speaking, business fundamentals, accounting, economics. They might sound boring, but if you have a broad foundation and take classes that you enjoy, it will make your senior year go by in an instant! Good luck!