Senior IT Risk Manager at Google
This question depends on how big and complicated the business might get. Being an entrepreneur generally speaking is tremendously time consuming and most people would rather dedicate that time to growing their business than accounting for it. If you plan on having more than a few employees, you'll want to invest in a professional bookkeeping service or hire an accountant who can handle most of the work without you needing to know more than the high level information which the Bookkeeper can explain to you. If you are thinking of staying small (< 3 people) with a relatively simple business model you can probably take a course on a specific type of software like Quickbooks to understand the basics.
College is what you make of it and degrees are primarily for employers to look at so if you plan on employing yourself, don't stress out too much. There's lots that might be useful to you like marketing strategies or business statistics. If you already know what your business will be, choose courses or a degree that you think will best prepare you to be successful in that business.