This is going to vary by location, employer, time of year, the economy, what your application/resume/cover letter are like, how well you fit the needs of the employer, and chance (maybe the hiring person's wife just had a baby and he's home with newborn and not answering his mail.). This is not a predictable question, sorry to say. After working for decades with job hunters, I've seen some folks get replies in one day and others get called in for an interview a full year after they applied. The more carefully you apply---to jobs for which your skills are needed---the faster you'll get a reply. So prepare for the job search as well as you can. get lots of advice and take most of it. Good Luck!