If you work for a Part 135 air carrier, you have a bit more flexibility, but it will still take time to build that seniority.
Thats a good question and the answer is yes and no. Airlines is ALL about seniority. So lets say you go to work for ABC Airline and that airline has 100 pilots. When you get hired by that airline of course you will be last person on that seniority list. So Unfortunately, when its time for pilots to bid for trips for the following month....you will get last pick or whatever the other 99 pilots did not pick. As time goes by, some senior pilots retire or pilots more senior than you leave the company, you will go up the seniority Ladder. When this starts happening, your chances of getting trips or destinations you like/want will become easier. Hopefully, there will be a time in your career that your seniority will be close to the top and thats when you will have The best chance of getting exactly what you want. You will be able to bid for not only trips/destinations you want but also what days you would like to fly. Initially, most likely, you will be flying not great trips and most likely fly Thursday-Sunday.....while a more senior pilot may be able to pick/bid for better destinations, more efficient trips and/or trips that allows him/her to be home on weekends.
The same seniority principle works for everything in the airlines: for picking up what base you will fly from, what airplane, getting captain upgrades, etc.
Hope this helps you. Let me know if you have any other questions
Carlos "Danny" recommends the following next steps: