Life after college can take some adjustment--some big and some small. Each person's experience is different because college and after college can vary so greatly.
When I was in school, I tried not to schedule early morning classes, and I was very much a night owl. My first job after school required me to be at work at 7:00 am. It also seemed really weird to me to go home at 3:30 and not take any work with me because I was getting paid by the hour. Luckily, I had co-oped so that made the transition into the workforce easier.
If your first after college job requires you to move to a new city or state, it can be a little lonely especially if you lived with friends. Many companies offer after work activities including sports and volunteer opportunities that can be a great way for you to meet people and discover more about your new home. My mother would also encourage you to find a new local place of worship as a way to to meet new people.
The ability to buy a house after graduating from school really depends on your local housing market and what type of house you want to buy. I was able to buy a house 2 years after graduating from college in a suburb of Columbia, SC. Unfortunately, I had to sell it less than a year later when I got the opportunity for a bigger role in a different state. Before buying a house, you may want to think about how long you plan to live in your first after college location