I would recommend taking all the AP and challenging classes you can handle. Colleges will look not only at your GPA and grades, but at the classes on your transcript. They want to see that you are challenging yourself, and taking harder courses, like AP or honors vs. normal classes. Plus, if you are able to take AP classes you might be eligible to earn college credit or test out of some courses. Most schools accept AP credits if you pass the AP test, but I would reach out to specific schools to verify their requirements/policies.
A word of warning: You should speak with your current academic advisor/counselor before registering for any AP or other challenging courses. You want to make sure you can handle to extra work load, and don't overwhelm yourself. Taking a bunch of honors courses is great, but not if you end up with D's or F's as your final grades. It also depends on what classes you are interested in or excel at. If you have historically done well in English/Literature classes, but struggle at math you would want to stick with normal math classes while challenging yourself with harder English courses.