I have no experience as a single parent, but I think the biggest challenge for you (assuming you have only one pre-req left) would be doing medical school and not actually getting in. Assuming you have good grades and a good MCAT, outside of coordinating the interview process, as a single parent you are at no disadvantage compared to other applicants. Traveling for/paying for interviews and figuring out childcare while you're gone would be difficult, but if you apply to mainly schools in your region this could become better. Do you have local relatives the kids could stay with while you're gone on interviews? As for being a single parent in medical school, you could spend the vast majority of your day at home as a preclinical student. Almost all preclinical lectures are recorded, and at many schools, most preclinical students don't attend live classes at all. Only exception to this would be anatomy lab, where you have to physically be there. Third and fourth year would be more challenging, as you have to be in clinic for the workday and would have to figure out childcare during the day.