I had an interview once where the very first question was "What is the difference between loyalty and integrity, which one is more important, and why?" Wow! I think the first thing to say is something to stall for a few seconds, such as "Wow! That's a truly original question!" Then, make sure you understand the question before you start to answer it. Ask for clarification, if necessary. Break it down into parts. It's really okay to answer half of it and then ask them to repeat the second half. Some people take notes during interviews. They ask first, "is it okay if i take notes?" This makes sense, esp. since they will likely cover the job duties and the compensation/benefits, but I have never felt comfortable doing it! And, if you have a notepad, you can write down the question! If you simply cannot answer the question, say so, and explain why. But, before doing that, try to provide an answer, even if you have to say, "no, i don't have any experience doing that, but, I do have experience doing XXXX which I think is somewhat similar." Sometimes I think that having a question we don't know the answer to makes us appear more human, and honest. Those who have rehearsed all the answers sometimes come across as telling you what they think you want to hear, as opposed to the truth. I'd much rather hire the person who I think is being the most candid!