Congrats on graduating! It's definitely a tough workforce out there and finding a spot in it can be frustrating especially since you just put in all that work to get a degree. Ken brought up some great ideas and I'd second that networking is EVERYTHING. Something else to add...don't hesitate to pinpoint EXACTLY what it is you want to do. This level of focus allows you to stay on course. If you're into graphic design and love baking why not look for a cooking web site that's looking for a graphic design artist? It may seem obvious but with the internet being inundated with information/opportunities it can be easy to get lost in it all.
Also as far as job applications go someone once gave me the great advice of applying to 5 jobs a day and give those 5 applications 110%. It's easy to start thinking "oh I need to submit applications until I get a phone call" - as long as you're putting your best self out there on paper an opportunity will come.
Best of luck - we've all been where you are and are pulling for you.