In addition to internships, it couldn't hurt to participate in volunteer opportunities that may allow you to strengthen skills in your spare time. Ask professionals in organizations, teams and groups you're a part of if they are aware of any opportunities within your field you could assist with. Assisting a friend or family member with their businesses, participating in work-sponsored activities, or joining weekly groups that will allow you to gain additional experience would be a great way for you to gain experience that may be applicable to your career in the future.
Seek out internships and co-op opportunities through your school or online. These provide very good opportunities for those with little to no experience. I worked 4 different internships in college and found all of them through the university placement office, bulletin board postings, and being involved with clubs on campus.
I don't know what year you are in college. If possible, work a summer job, but not a low-level fast-food type job... try to find something in your area. Talk to people in your field to find out if any low-level positions in their company and/or ask them to refer you to anyone who might know of an opportunity. Ask, ask, ask... with persistence (and a little luck), you will find something to get you started. Be prepared for low (or no) pay and grunt work. Nice to think "but I have a degree", but nearly everyone has to start at the bottom, and it provides you with a great knowledge base as you work your way up.
If you are still in college, join a group! The best option is one related to your career field, but if not available, join another group or volunteer with a local organization. Surprisingly, there are many activities that can be related to "work experience" that are not official, paid jobs. Be creative and think about the skills you are looking for and tie what you do to what want to emphasize as job experience.
Sheryl recommends the following next steps: